TABLE 1.

Demographic and clinical characteristics of included and excluded participants in analysis 1: impact of PRS on psychosis risk prediction in persons at clinical high risk and unaffected comparison subjects^a

Characteristic	Clinical High Risk, Psychosis Converter				Clinical High Risk, Nonconverter				Unaffected Comparison Subjects
	Excludedb (N=14)		Included (N=80)		Excludedc (N=422)		Included (N=248)		Excludedd (N=63)		Included (N=216)
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Age (years)	16.90	4.01	18.27	3.50	18.24	4.15	19.09	4.53	19.21	4.48	19.91	4.71
Maternal educatione	6.23	1.42	6.54	1.73	6.29	1.66	6.35	1.54	6.97	1.47	6.79	1.49
Paternal educatione	5.62	1.89	6.42	1.78	6.20	1.77	6.28	1.66	6.61	1.56	6.51	1.68
	N	%	N	%	N	%	N	%	N	%	N	%
Male	9	64.3	50	62.5	238	56.5	138	55.6	32	50.8	109	50.5
Family history of psychosis	2	14.3	16	20.3	54	12.9	45	18.1
Psychiatric diagnoses
Schizophrenia spectrum disordersf	7	50.0	34	40.0
Psychosis not otherwise specified	6	42.9	28	35.0
Major depression with psychosis	0	0.0	1	1.3
Bipolar disorder with psychosis	0	0.0	6	7.5
Unknown	1	7.1	11	13.7
Self-reported ancestry
European	6	42.9	47	58.8	252	60.0	136	54.8	31	49.2	121	56.0
African (e.g., African, African Caribbean)	1	7.1	11	13.8	53	12.6	53	21.4	6	9.5	42	19.4
Interracial	4	28.6	10	12.5	50	11.9	33	13.3	12	19.0	17	7.9
Central or South American	2	14.3	2	2.5	22	5.2	8	3.2	5	7.9	8	3.7
South Asian (e.g., East Indian, Pakistani, Sri Lankan)	1	7.1	3	3.8	8	1.9	6	2.4	1	1.6	7	3.2
East Asian (e.g., Chinese, Japanese, Korean)	0	0.0	4	5.0	22	5.2	7	2.8	5	7.9	17	7.9
First Nations (e.g., North American Indian, Métis, Inuit)	0	0.0	1	1.2	7	1.7	3	1.2	1	1.6	3	1.4
Native Hawaiian/Pacific Islander	0	0.0	1	1.2	1	0.2	1	0.4	1	1.6	0	0.0
West/Central Asian and Middle Eastern (e.g., Egyptian, Lebanese, Emirati [United Arab Emirates], Afghan, Iranian)	0	0.0	1	1.2	5	1.2	1	0.4	1	1.6	1	0.5
Missing	0	0.0	0	0.0	1	0.0	0	0.0	0	0.0	0	0.0

^aThere were no significant differences between excluded and included individuals in any of the three groupings except in age for the clinical high-risk nonconverter group (p=0.014) and in self-reported ancestry for the unaffected comparison group (p=0.05).

^bReasons for exclusion among psychosis converters: no DNA sample available (N=12), did not meet high-risk criteria from the Criteria for Psychosis-Risk States (N=2).

^cReasons for exclusion among nonconverters: sibling exclusion (N=3), only did not meet high-risk criteria from the Criteria for Psychosis-Risk States (N=6), only no DNA sample available (N=25), only less than 2 years of follow-up (N=239), no DNA sample available and did not meet high-risk criteria from the Criteria of Psychosis-Risk States (N=3), less than 2 years of follow-up and did not meet high-risk criteria from the Criteria of Psychosis Risk States (N=5), less than 2 years of follow-up and no DNA sample available (N=131), less than 2 years of follow-up and sibling exclusion (N=5), less than 2 years of follow-up and no DNA sample available and did not meet high-risk criteria from the Criteria of Psychosis-Risk States (N=5).

^dReasons for exclusion for unaffected individuals: sibling exclusion (N=11), no DNA sample available (N=52).

^eParental education is scaled from 1 to 9, where 1=no schooling, 2=some primary school, 3=completed primary school, 4=some high school, 5=completed high school, 6=some college/technical school/undergraduate, 7=completed college/technical school/undergraduate, 8=some graduate/professional school, and 9=completed graduate/professional school.

^fSchizophrenia spectrum disorders included schizophrenia, schizophreniform disorder, schizoaffective disorder, and delusional disorder.