Study | Reason for exclusion |
---|---|
Angelucci 2012 | Study not randomised, not controlled. Prospective, 1‐year, multi‐centre, single‐arm trial including 152 lower risk and transfusion dependent MDS patients. |
Brosnahan 2008 | Case report of MDS patient with acute interstitial nephritis. |
Cermak 2013 | Study not randomised. Comparative study on 48 patients receiving deferiprone (January 2006 to July 2007) and 65 patients receiving deferasirox (January 2008 to August 2010). |
Di Tucci 2007 | Case report of patient with primary myelofibrosis (PMF). |
Fox 2009 | Study not randomised. Matched‐pair analysis on 186 MDS patients. |
García‐Delgado 2009 | Study not randomised, not controlled. Single‐arm study evaluating the effect of deferasirox on oxidative stress and vascular dysfunction in MDS patients with iron overload (4 people with MDS). |
Gattermann 2007, EPIC | Study not randomised, not controlled. Prospective, 1‐year, multi‐centre, single‐arm, open‐label phase IIIB/IV trial (1744 people with various transfusion‐dependent anaemias including 341 people with MDS and 116 with AA). |
Gattermann 2009 | Study not randomised, not controlled. Prospective, multi‐centre, post‐marketing, single‐arm study on 123 chelation‐naive (Extend) and 44 pre‐chelated (Exjange) MDS patients. |
Ghoti 2009 | Study not randomised, not controlled. Single‐arm study evaluating decrease in intra‐ and extra‐cellular free iron species and oxidative stress parameters during treatment with deferasirox in iron‐loaded patients with MDS. |
Greenberg 2006, US2 study | Study not randomised, not controlled. Prospective, phase II, multi‐centre, single‐arm study on 30 people with MDS. |
Leitch 2007 | Study not randomised, not controlled. Retrospective analysis of 41 people with PMF. |
Leitch 2009 | Case report. |
List 2006, US3 study | Study not randomised, not controlled. Prospective, phase II, open‐label, single‐arm study on 176 people with MDS. |
Messa 2008 | Retrospective case series of 7 people with MDS and 3 people with PMF. |
Metzgeroth 2009 | Study not randomised, not controlled. Prospective, phase II, open‐label, single‐arm, single‐centre study of 12 people with MDS. |
Min 2008 | Study not randomised, not controlled. Prospective, multi‐centre, open‐label, single‐arm study of 29 people with MDS and 50 people with AA. |
Miyazawa 2006 | Study not randomised, not controlled. Prospective, phase I, open‐label, multi‐centre, dose‐escalation study on 26 people with MDS or AA. |
Nolte 2013 | Study not randomised, not controlled. Open label, 1‐year, single‐arm, multi‐centre trial on 50 patients with low and intermediate‐1 risk MDS and transfusional iron overload. |
Peng 2013 | Study on patients with thalassemia (Chinese full text not available; assessment based on English abstract and references). |
Pennell 2014, CORDELIA | Study planned to include MDS patients; however, of the four screened patients with MDS, none fulfilled the inclusion criteria. |
Porter 2004 | Study not randomised, not controlled. Prospective, phase II, single‐arm study of 184 people with transfusion‐dependent anaemia including 47 people with MDS. |
Rachmilewitz 2008 | Study not randomised, not controlled. Prospective, single‐arm study of 15 people with MDS. |
Remacha 2010 | Study not randomised, not controlled. Cross‐sectional study on 549 MDS patients. |
Rose 2007 | Study not randomised, not controlled. Survey of 170 people with MDS from 18 French GFM centres. |
Wimazal 2009 | Case series of 14 MDS patients treated with deferasirox (500 to 1500 mg/day) for up to 24 months. |
Only reports on observational studies or case series are mentioned in this table.
AA ‐ aplastic anaemia;
GFM ‐ Groupe Francophone des Myelodysplasies;
MDS ‐ myelodysplastic syndrome;
PMF ‐ primary myelofibrosis.