Table 3. . Association analyses of Composite Pain Index with phenylethanolamine N-methyltransferase polymorphisms.

Single-nucleotide polymorphism	Model	B† (97.5% CI)	p-value
	Additive (AA vs AG vs GG)	1.51 (-3.42–6.43)	0.546
rs5638	Dominant (AA vs AG + GG)	2.12 (-3.00–7.24)	0.413
	Recessive (AA + AG vs GG)	-13.76 (-40.75–13.23)	0.315
	Additive (GG vs GT vs TT)	0.36 (-5.73–6.44)	0.908
rs2934965	Dominant (GG vs GT + TT)	0.21 (-6.33–6.76)	0.949
	Recessive (GG + GT vs TT)	3.44 (-23.72–30.59)	0.803
	Additive (GG vs GA vs AA)	-1.75 (-5.65–2.15)	0.376
rs876493	Dominant (GG vs GA + AA)	-2.64 (-7.44–2.15)	0.278
	Recessive (GG + GA vs AA)	-0.06 (-9.45–9.34)	0.991
	Additive (CC vs CG vs GG)	-0.14 (-4.76–4.48)	0.952
rs2941523	Dominant (CC vs CG + GG)	0.95 (-4.26–6.16)	0.719
	Recessive (CC + CG vs GG)	-10.37 (-26.07–5.33)	0.194

^†Unstandardized regression coefficient.

Regression models are adjusted for covariates (age, sex and sickle cell type).