Table 4. . Association analyses of utilization scores with phenylethanolamine N-methyltransferase polymorphisms.

Single-nucleotide polymorphism	Model	Incidence risk ratio (97.5% CI)	p-value
	Additive (AA vs AG vs GG)	0.96 (0.66–1.41)	0.839
rs5638	Dominant (AA vs AG + GG)	0.98 (0.67–1.46)	0.930
	Recessive (AA + AG vs GG)	0.33 (0.01–5.97)	0.412
	Additive (GG vs GT vs TT)	0.61 (0.38–1.01)	0.044*
rs2934965	Dominant (GG vs GT + TT)	0.63 (0.38–1.06)	0.073
	Recessive (GG + GT vs TT)	0.15 (0.01–2.72)	0.164
	Additive (GG vs GA vs AA)	0.68 (0.51–0.93)	0.012*
rs876493	Dominant (GG vs GA + AA)	0.67 (0.47–0.97)	0.030*
	Recessive (GG + GA vs AA)	0.51 (0.24–1.15)	0.088
	Additive (CC vs CG vs GG)	0.68 (0.47–0.99)	0.033*
rs2941523	Dominant (CC vs CG + GG)	0.73 (0.49–1.09)	0.115
	Recessive (CC + CG vs GG)	0.12 (0.02–0.65)	0.017*

^†Regression models are adjusted for covariates (age, sex and sickle cell type).

*p-values < 0.05.