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Graphic abstract. HF heart failure, MRA mineralocorticoid receptor antagonist, ICD implantable cardioverter-defibrillator, CRT cardiac resynchronization therapy, CCM cardiac contractility modulation, VNS vagal nerve stimulation, LVAD left ventricular assist device, BAT baroreflex activation therapy, T2DM type 2 diabetes mellitus, AF atrial fibrillation, MR mitral regurgitation, CSA central sleep apnoea
