Table 4.
Comparison of mean changes in diffusion metrics (fractional anisotropy and mean diffusivity) over time between intervention and usual-care (control) groups.
| Usual care group (Control) | Intervention group | p-values (FWE-corrected) | |
|---|---|---|---|
| Change in fractional anisotropy | |||
| Left CST | 0.125 (0.112) | 0.094 (0.027) | p = 0.586 |
| Right CST | 0.120 (0.111) | 0.090 (0.024) | p = 0.574 |
| CC | 0.188 (0.063) | 0.146 (0.132) | p = 0.497 |
| Change in mean diffusivity (10−3mm2s−1) | |||
| Left CST | 0.334 (0.358) | 0.221 (0.091) | p = 0.374 |
| Right CST | 0.295 (0.318) | 0.217 (0.121) | p = 0.642 |
| CC | 0.890 (0.936) | 0.665 (0.585) | p = 0.851 |
The model was controlled for age, gender, years of education, APOE4, and baseline cognitive status. CC, corpus callosum; CST, corticospinal tract.