Figure 1.

PCT system. The PCT system consists of an illumination device and a series of plastic containers. The disposable set provides a single‐use, closed, integrated system for pathogen inactivation treatment of a PLT product (300 mL). The PLT product in a mixture of 35 percent plasma and 65 percent InterSol (PAS III) is connected via a sterile connection device and passed through a container of amotosalen‐HCl (also known as S‐59) into an illumination container (Step 1). The integrated set is placed in the UVA illumination device that provides a 3 J per cm² dose of UVA to the mixture (Step 2). After illumination for 3 to 6 minutes, the PLTs are transferred to a second container for treatment with a compound adsorption device (CAD) to lower the levels of residual amotosalen and free photoproducts (Step 3). After a minimum of 4 hours of CAD treatment, the PCT PLTs are transferred to a PL‐2410 plastic container for storage up to 5 days (Step 4). The CAD step was not used in the viral inactivation experiments described in this report.