Table 1.
Laboratory data of the patients with β-thalassemia and treatment with thalidomide.
| Parameters | NTDT | TDT | ||||||
|---|---|---|---|---|---|---|---|---|
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| Before | After | P value | Before | After | P value | |||
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| Hb (g/dl) | 3M (n=39) | 6.8±1.1 | 9.7±1.9 | <0.001 | 3M (n=23) | 6.1±1.7 | 8.5±1.4 | <0.001 |
| 12M (n=20) | 7.0±1.0 | 10.2±1.8 | <0.001 | 12M (n=14) | 5.6±1.8 | 9.1±1.6 | <0.001 | |
| 24M (n=7) | 7.1±0.7 | 10.0±1.5 | <0.001 | 24M (n=4) | 4.8±2.0 | 9.9±1.1 | <0.001 | |
| RBC(×1012/L) | 3M (n=39) | 3.3±0.7 | 4.7±0.9 | <0.001 | 3M (n=23) | 2.7±0.7 | 4.0±0.7 | <0.001 |
| 12M (n=20) | 3.4±0.5 | 4.9±1.0 | <0.001 | 12M (n=14) | 2.4±0.7 | 4.3±0.8 | <0.001 | |
| 24M (n=7) | 3.4±0.4 | 4.5±1.0 | 0.002 | 24M (n=4) | 2.2±0.7 | 4.7±0.3 | 0.007 | |
| HbF(%) | 3M (n=32) | 41.9±23.4 | 54.3±23.0 | <0.001 | 3M (n=14) | 34.7±21.3 | 52.2±22.7 | <0.001 |
| 12M (n=11) | 38.9±22.3 | 46.4±20.3 | 0.047 | 12M (n=5) | 35.6±22.6 | 60.8±18.8 | 0.015 | |
| 24M (n=6) | 39.1±19.4 | 44.1±20.1 | 0.023 | - | - | - | - | |
| NRBC (%) | 3M (n=29) | 176.6±215.1 | 63.8±90.9 | <0.001 | 3M (n=14) | 283.4±645.0 | 194.3±267.4 | 0.553 |
| 12M (n=14) | 178.4±208.6 | 86.7±102.5 | 0.015 | 12M (n=5) | 38.8±45.2 | 7.3±8.9 | 0.138 | |
| 24M (n=3) | 393.0±205.7 | 251.3±182.1 | 0.068 | - | - | - | - | |
| Ret (%) | 3M (n=27) | 7.7±5.0 | 7.7±5.7 | 0.957 | 3M (n=12) | 6.9±7.0 | 6.6±6.4 | 0.824 |
| 12M (n=10) | 6.6±6.0 | 8.7±7.6 | 0.468 | 12M (n=4) | 2.3±1.6 | 8.0±7.4 | 0.249 | |
| 24M (n=5) | 10.3±7.0 | 11.4±9.5 | 0.784 | 24M (n=3) | 3.1±1.4 | 3.8±2.6 | 0.597 | |
| MCV (fL) | 3M (n=39) | 71.3±9.1 | 66.6±7.8 | <0.001 | 3M (n=23) | 72.6±8.1 | 69.1±7.9 | 0.005 |
| 12M (n=20) | 70.0±8.0 | 66.2±7.7 | 0.039 | 12M (n=14) | 71.0±9.3 | 66.6±9.0 | 0.031 | |
| 24M (n=7) | 71.0±7.5 | 69.7±3.9 | 0.452 | 24M (n=4) | 66.0±7.4 | 65.3±5.6 | 0.624 | |
| MCH (pg) | 3M (n=39) | 21.3±2.8 | 20.7±2.9 | 0.168 | 3M (n=23) | 22.6±2.8 | 21.5±2.4 | 0.014 |
| 12M (n=20) | 20.7±2.6 | 20.5±2.2 | 0.610 | 12M (n=14) | 22.0±3.0 | 21.5±2.5 | 0.421 | |
| 24M (n=7) | 20.8±2.2 | 21.5±1.5 | 0.166 | 24M (n=4) | 21.0±2.8 | 21.1±2.2 | 0.818 | |
| MCHC (g/L) | 3M (n=39) | 299.2±19.1 | 314.3±15.0 | <0.001 | 3M (n=23) | 311.0±14.0 | 312.0±14.3 | 0.793 |
| 12M (n=20) | 297.2±18.4 | 310.5±18.1 | 0.001 | 12M (n=14) | 310.2±13.9 | 322.5±19.9 | 0.020 | |
| 24M (n=7) | 294.6±15.2 | 309.1±12.1 | 0.006 | 24M (n=4) | 316.3±10.5 | 323.5±21.7 | 0.342 | |
| TBIL (μmol/L) | 3M (n=36) | 67.7±28.6 | 54.9±22.8 | 0.001 | 3M (n=22) | 55.3±27.7 | 51.9±24.2 | 0.205 |
| 12M (n=19) | 69.8±30.8 | 55.5±20.8 | 0.008 | 12M (n=10) | 47.6±22.6 | 44.2±30.0 | 0.395 | |
| 24M (n=7) | 78.7±40.5 | 62.7±30.4 | 0.125 | 24M (n=3) | 47.4±12.3 | 48.9±19.3 | 0.851 | |
| IBIL (μmol/L) | 3M (n=36) | 50.0±26.9 | 41.4±23.8 | 0.012 | 3M (n=22) | 38.7±21.0 | 35.9±20.6 | 0.228 |
| 12M (n=19) | 50.5±27.0 | 39.6±20.2 | 0.052 | 12M (n=10) | 34.0±23.3 | 31.7±26.6 | 0.278 | |
| 24M (n=7) | 63.1±39.7 | 45.0±28.8 | 0.110 | 24M (n=3) | 34.7±13.2 | 31.5±14.8 | 0.581 | |
| LDH (IU/L) | 3M (n=20) | 412.2±207.6 | 263.4±186.3 | <0.001 | 3M (n=10) | 329.3±127.2 | 238.3±115.1 | 0.004 |
| SF (ng/ml) | 3M (n=30) | 1821.6±1488.3 | 2158.5±1529.5 | 0.039 | 3M (n=18) | 3035.3±2280.4 | 3848.5±2827.7 | 0.043 |
| 12M (n=18) | 1928.7±1483.0 | 2693.3±2032.6 | 0.009 | 12M (n=8) | 2303.1±1850.3 | 3442.4±2099.7 | 0.026 | |
| 24M (n=7) | 1595.3±1021.2 | 2654.0±1882.6 | 0.025 | 24M (n=3) | 1449.7±772.9 | 1924.1±342.6 | 0.402 | |
Abbreviations: NTDT: non-transfusion-dependent thalassemia; TDT: transfusion-dependent thalassemia; Hb: hemoglobin; HbF: fetal hemoglobin; RBC: red blood cell count; NRBC: nucleated red blood cells; Ret: reticulocyte; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; TBIL: total bilirubin; IBIL: indirect bilirubin; LDH: lactate dehydrogenase; SF: serum ferritin.