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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Trends Pharmacol Sci. 2020 Mar 26;41(5):305–317. doi: 10.1016/j.tips.2020.02.006

Fig. 2. Chemical structures of representative degrader molecules: thalidomide, example of a “molecular glue” compound, ARV-825 and dBET-1, examples of PROTAC compounds.

Fig. 2.

As clearly indicated, the two PROTAC molecules have an E3 recruiting arm (thalidomide-derived warhead optimized to bind E3 ligase cereblon (CRBN)), a protein-of-interest (POI) recruiting arm (JQ1 warhead targeted towards BET bromodomain containing proteins), and a variable linker.