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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Gut. 2018 Jun 22;68(6):1003–1013. doi: 10.1136/gutjnl-2018-316226

Fig. 2. Inhibition of CXCR4 by AMD3100 blocks LGG-induced migration of COX2 expressing MSCs and LGG-induced radioprotection in mice.

Fig. 2.

(A) Immunofluorescence for COX2 in the small intestine shows an increased percentage of MSCs in the crypt zone of LGG-treated mice compared with controls or mice treated with LGG and AMD3100 treated mice. Dotted yellow line separates crypt and villus zones. (B) Cell counts provide quantitative data indicating that LGG-induced migration of COX2 expressing MSCs from the villus to the crypt zone, and that AMD3100 blocks LGG induced migration. Data are means ± SEM for 5 to 7 mice per treatment group. ***P<.0001 compared with controls. (C) Crypt survival is significantly improved in LGG treated mice, and AMD3100 blocks LGG induced radioprotection. Data are means ± SEM for 5 to 7 mice per treatment group. **P<.005 compared with irradiated controls.