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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: Gut. 2018 Jun 22;68(6):1003–1013. doi: 10.1136/gutjnl-2018-316226

Fig. 3. LGG induces CXCL12 in pericryptal macrophages.

Fig. 3.

(A,B) Mice were given LGG or vehicle by gavage and sacrificed 24 hours later. Laser Capture Microdissection (LCM) was performed and analyzed by gene chip. (A) Figure illustrates the relative expression of gene expression in the pericryptal mRNA from LGG treated and vehicle treated mice. Dotted lines represent 2 standard deviations from the means. Genes for chemokines, chemokine receptors and enzymes related to arachidonic acid metabolism are shown. (B) Table presents data for chemokine receptors, chemokines and arachidonic acid metabolism genes, comparing gene expression in pericryptal cells from vehicle treated and LGG treated mice. (C) Immunofluorescence for CXCL12(red) and F4/80(green) in mouse small intestines shows that some macrophages, including pericryptal macrophages (arrows), express CXCL12.