Comparison 3. As needed (PRN) or extended‐fixed versus other extended‐fixed injections.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
3.1 Mean change in best‐corrected visual acuity	2		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.1.1 PRN (1) vs every 12 weeks (2); follow‐up at 2 years	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.1.2 Every 12 weeks (1) vs every 6 weeks (2); follow‐up at 1 year	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.2 Gain ≥ 15 letters visual acuity	2		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3.2.1 PRN vs every 12 weeks; follow‐up at 2 years	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3.2.2 Every 12 weeks vs every 6 weeks; follow‐up at 1 year	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3.3 Mean change in central retinal thickness	2		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.3.1 PRN vs every 12 weeks; follow‐up at 2 years	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.3.2 Every 12 weeks vs every 6 weeks; follow‐up at 1 year	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected