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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Curr Osteoporos Rep. 2019 Aug;17(4):157–168. doi: 10.1007/s11914-019-00514-0

Figure 1: Homeostatic control of bone mass and quality by osteoblasts, osteoclasts, and osteocytes.

Figure 1:

During homeostasis (green region), optimal cellular activity of osteoblasts and osteoclasts maintains bone resistance to fracture. Unopposed changes in osteoblast or osteoclast function lead to changes in bone mass that can cause bone fragility (red regions). Osteocyte PLR also contributes to the mechanical homeostasis of bone. As for osteoblasts and osteoclasts, the effect of osteocyte PLR on bone quality is non-linear. Too much or too little osteocytic PLR can compromise bone quality.