Table 2.

Risk factors for development of Clostridium difficile infection after detection of H pylori using multivariable logistic regression model

	Odds ratio (95% CI)	P-value
Age at H pylori diagnosis *	0.91 (0.87–0.96)	P<0.001
Female gender	1.74 (1.20–2.52)	0.003
Race		0.002
White	REFERENCE
Black or African American	0.63 (0.45–0.85)
American Indian or Alaska Native	0.43 (0.06–3.08)
Asian	0.63 (0.09–4.53)
Native Hawaiian or Pacific Islander	0.83 (0.20–3.48)
Unknown	0.52 (0.37–0.73)
Smoking history	0.76 (0.56–1.02)	0.07
Recent hospitalization prior to Clostridium difficile diagnosis		P<0.001
None	REFERENCE
Discharged within 12 weeks	2.15 (1.22–3.77)
Discharged within 4 weeks	3.46 (2.18–5.48)
Prior history of Clostridium difficile	12.5 (9.21 −17.0)	P<0.001

^*Per 5-year increase of age

Other covariates tested but not included in the final multivariable model as they were not significant (p ≥ 0.1) were: ethnicity, poverty level of patient’s zip code of residence at time of H pylori diagnosis, treatment of H pylori, categorized by antibiotic regimen, PPI use (choice of PPI, dose, duration)