Table 3.

Risk factors for development of Clostridium difficile infection after treatment of H pylori using multivariable logistic regression model

	Odds ratio (95% CI)	P-value
Age at H pylori diagnosis *	0.91 (0.86–0.96)	P<0.001
Female gender	1.54 (1.00–2.37)	0.05
Smoking history	0.71 (0.51–0.99)	0.04
Recent hospitalization prior to Clostridium difficile diagnosis		P<0.001
None	REFERENCE
Discharged within 12 weeks	2.10 (1.08–4.08)
Discharged within 4 weeks	3.18 (1.86–5.43)
Prior history of Clostridium difficile	13.3 (9.38 −18.9)	P<0.001
Eradication confirmation of H pylori		0.0003
Not eradicated	REFERENCE
Confirmed eradicated	1.49 (0.67–3.29)
Unknown eradication status	0.81 (0.37–1.78)

^*Per 5-year increase of age

Other covariates tested but not included in the final multivariable model as they were not significant (p ≥ 0.1) were: race, ethnicity, poverty level of patient’s zip code of residence at time of H pylori diagnosis