Table 4.
Top 25 significantly enriched Ingenuity canonical pathways in the hepatic transcriptome comparing E. coli challenged to non-challenged cows (NaN, no activation score).
| Ingenuity canonical pathways | –log (p-value) | Ratio | z-score |
|---|---|---|---|
| Protein ubiquitination pathway | 9.44E+00 | 4.42E-01 | NaN |
| Sirtuin signaling pathway | 8.41E+00 | 4.15E-01 | −1.43 |
| Acute phase response signaling | 6.62E+00 | 4.48E-01 | 2.56 |
| Estrogen receptor signaling | 6.53E+00 | 4.77E-01 | NaN |
| Adipogenesis pathway | 6.31E+00 | 4.67E-01 | NaN |
| FXR/RXR activation | 6.03E+00 | 4.60E-01 | NaN |
| Regulation of eIF4 and p70S6K signaling | 5.86E+00 | 4.41E-01 | 0.35 |
| mTOR signaling | 5.62E+00 | 4.15E-01 | −1.58 |
| 3-phosphoinositide biosynthesis | 5.52E+00 | 4.11E-01 | −1.07 |
| Integrin signaling | 5.51E+00 | 4.09E-01 | −2.71 |
| LXR/RXR activation | 5.36E+00 | 4.53E-01 | −3.68 |
| Superpathway of inositol phosphate compounds | 5.27E+00 | 3.94E-01 | −1.98 |
| D-myo-inositol-5-phosphate metabolism | 5.06E+00 | 4.23E-01 | −0.59 |
| 3-phosphoinositide degradation | 4.86E+00 | 4.21E-01 | −0.60 |
| EIF2 signaling | 4.60E+00 | 3.93E-01 | 2.61 |
| RAN signaling | 4.59E+00 | 7.37E-01 | NaN |
| D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis | 4.58E+00 | 4.23E-01 | −0.13 |
| D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis | 4.58E+00 | 4.23E-01 | −0.123 |
| Unfolded protein response | 4.44E+00 | 5.27E-01 | NaN |
| Glioma invasiveness signaling | 4.41E+00 | 4.93E-01 | −1.52 |
| Complement system | 4.31E+00 | 5.79E-01 | −2.14 |
| Production of nitric oxide and reactive oxygen species in macrophages | 4.29E+00 | 3.95E-01 | −2.29 |
| Macropinocytosis signaling | 4.13E+00 | 4.69E-01 | −0.39 |
| LPS/IL-1 mediated inhibition of RXR function | 4.09E+00 | 3.83E-01 | 2.65 |
| Phagosome formation | 3.98E+00 | 4.20E-01 | NaN |