Figure 6.

Levels of neutrophils and classical and nonclassical monocytes as inactive relapsing-remitting multiple sclerosis (RRMSi) markers. Lin⁺ lymphocytes, Lin⁻ SSC^hi granulocytes, CD15⁺ neutrophils, and monocyte subpopulations were identified and quantified in MS study participants stratified by disease course type [active progressive MS (PMSa): n = 14, inactive progressive MS (PMSi): n = 13, active relapsing-remitting MS (RRMSa): n = 8, and inactive relapsing-remitting MS (RRMSi): n = 30] as presented in Supplementary Figure S1. Myeloid signature was calculated as an optimally weighted sum of percentages of neutrophils and classical and nonclassical monocytes within CD45⁺ pan leukocytes. Receiver operating curves (ROCs) display sensitivity and specificity of each parameter as a marker to differentiate between RRMSi and other MS disease courses. In the plots, optimal parameter cutoffs are displayed. In the legends, values of areas under the curve (AUCs) for each ROC are presented with the 95% CI in parentheses. (A) Levels of myeloid cell populations and Lin⁺ lymphocytes expressed as percentage of CD45⁺ cells. (B) Levels of myeloid cell populations and Lin⁺ lymphocytes expressed as count per microliter of whole blood. (C) Myeloid signature.