FIGURE 1.

Core body temperature is lower in mice globally lacking kisspeptin signaling. A, In gonad-intact (n = 4/group) and B, chronically OVX mice (n = 5–8/group), global Kiss1r KO females have lower body temperature than WT littermates, primarily during the dark phase of the light cycle. C, Cold exposure at 4°C for 6 hours causes a sharper drop in body temperature in OVX global Kiss1r KOs than OVX WT controls (n = 6/group). *P < .05