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. Author manuscript; available in PMC: 2020 May 6.
Published in final edited form as: FASEB J. 2019 Nov 19;34(1):107–121. doi: 10.1096/fj.201901600R

FIGURE 2.

FIGURE 2

Thermogenic gene expression is decreased in BAT of global Kiss1r KO mice. A, In ovary-intact mice, BAT weight is normal but mRNA levels of Ucp1 (protein in the BAT mitochondria used to generate heat by non-shivering thermogenesis), Cox8b (polypeptide of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport), and Prdm16 (transcriptional coregulator promoting thermogenic processes in BAT) are significantly decreased in global Kiss1r KOs compared to WT littermates (n = 10–12/group). B, In chronically OVX females, BAT weight remains normal but Ucp1 and Cox8b expression are still reduced in global Kiss1r KOs versus WT controls (n = 6–8/group). *P < .05; **P < .01, ***P < .001