Table 6. Gene-gene interaction models contribution to BA risk by GMDR analysis.
Number of factors | Best model a | Training accuracy | Testing accuracy | CVC | Chi2 | P value | OR(95% CI) |
1 | rs17095355 | 0.5663 | 0.5637 | 10/10 | 10.4962 | 0.0012 | 1.89(1.28-2.78) |
2 | rs7577243-rs17095355 | 0.5782 | 0.5216 | 6/10 | 12.8256 | 0.0003 | 1.94(1.35-2.79) |
3 | rs11125609-rs7577243-rs17095355 | 0.6072 | 0.5713 | 10/10 | 23.2364 | <0.0001 | 2.41(1.68-3.46) |
a. The best model was referred to as the one with the maximum testing accuracy and maximum cross-validation consistency (CVC). GMDR: generalized multifactor dimensionality reduction; OR: odds ratio; CI: confidence interval. Rs17095355, rs7577243 and rs11125609 were on ADD3, GPC1 and EFEMP1, respectively.