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Our hypothesis that exercise training suppressed inflammatory and apoptotic pathways and enhanced IGF1R/PI3K/Akt survival and anti-aging AMPK/SIRT1/PGC-1α associated pathways in the hippocampus of D-galactose induced aging rats. These aging attenuated IGF1R related PI3K/Akt survival pathway and AMPK/SIRT1/PGC-1α pathway were improved after exercise training. Activated inflammatory and apoptotic activity were prevented after exercise training.
