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. 2020 Apr 15;12(8):6990–7005. doi: 10.18632/aging.103056

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Copyright © 2020 Han et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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USP22-pivot gene-module-pathway network suggesting USP22 could affect multiple pathways by up-regulating UBC. (A) USP22 regulates the modules by regulating pivot genes in the development of LUAD. (B) Knocking down USP22 up-regulate UBC to result in affecting lysosome pathway. (C) Knocking down USP22 up-regulates UBC to affect cell cycle pathway. (D) Knocking down USP22 could up-regulate UBC to affect the proteolysis pathway mediated by ubiquitin. Blue indicates down-regulated expression, while red indicates up-regulated expression.