Table 2. Associations of ATM gene with DFS and OS in patients with NSCLC.
| SNP | Disease-free survival | Overall survival | ||||||||
| Event/No. | MST | Pa | Adjusted HR (95%CI) | Pb | Event/No. | MST | Pa | Adjusted HR (95%CI) | Pb | |
| rs664143 | ||||||||||
| GG | 58/148 | 33.4 | 0.008 | 1.00 | 43/148 | 44.0 | 0.029 | 1.00 | ||
| GA | 219/381 | 24.3 | 1.41(1.05-1.89) | 0.023 | 166/381 | 37.8 | 1.22(1.17-1.72) | 0.014 | ||
| AA | 106/191 | 22.7 | 1.38(1.01-1.91) | 0.034 | 84/191 | 33.6 | 1.40(1.23-2.04) | 0.024 | ||
| Trend | ||||||||||
| GG | 58/148 | 33.4 | 0.002 | 1.00 | 43/148 | 44.0 | 0.023 | 1.00 | ||
| GA+AA | 325/571 | 23.8 | 1.40(1.05-1.86) | 0.021 | 250/572 | 35.9 | 1.28(1.12-1.78) | 0.040 | ||
| GG+GA | 277/528 | 26.0 | 0.248 | 1.00 | 209/529 | 36.1 | 0.049 | 1.00 | ||
| AA | 106/191 | 22.7 | 1.06(0.85-1.33) | 0.596 | 84/191 | 33.6 | 1.20(0.93-1.55) | 0.164 | ||
| rs664677 | ||||||||||
| TT | 142/265 | 25.5 | 0.929 | 1.00 | 115/265 | 42.7 | 0.670 | 1.00 | ||
| TC | 152/282 | 24.1 | 1.11(0.88-1.40) | 0.379 | 116/282 | 38.7 | 1.13(0.87-1.47) | 0.348 | ||
| CC | 89/173 | 28.0 | 1.02(0.78-1.33) | 0.874 | 62/173 | 32.7 | 0.97(0.71-1.32) | 0.852 | ||
| Trend | ||||||||||
| TT | 160/259 | 25.5 | 0.928 | 1.00 | 115/265 | 42.7 | 0.888 | 1.00 | ||
| TC+CC | 241/455 | 24.5 | 0.97(0.77-1.22) | 0.777 | 178/455 | 35.7 | 1.07(0.85-1.36) | 0.575 | ||
| TT+TC | 294/547 | 28.0 | 0.766 | 1.00 | 231/547 | 33.4 | 0.465 | 1.00 | ||
| CC | 48/79 | 24.5 | 0.88(0.67-1.15) | 0.344 | 62/173 | 32.7 | 0.91(0.69-1.21) | 0.531 | ||
| rs189037 | ||||||||||
| AA | 94/172 | 31.0 | 0.007 | 1.00 | 56/172 | 43.5 | <0.001 | 1.00 | ||
| AG | 221/383 | 23.8 | 1.48(1.18-2.03) | 0.014 | 192/383 | 34.9 | 1.76(1.21-2.45) | 0.001 | ||
| GG | 68/165 | 24.5 | 1.32(1.17-1.91) | 0.012 | 45/165 | 33.5 | 1.23(1.13-1.83) | 0.029 | ||
| Trend | ||||||||||
| AA | 94/172 | 31.0 | 0.004 | 1.000 | 53/172 | 43.5 | 0.001 | 1.00 | ||
| AG+GG | 289/548 | 24.1 | 1.44(1.06-1.95) | 0.019 | 237/548 | 36.0 | 1.16(1.17-2.21) | 0.004 | ||
| AA+AG | 315/555 | 24.7 | 0.523 | 1.00 | 248/555 | 37.8 | 0.145 | 1.00 | ||
| GG | 68/165 | 24.5 | 0.98(0.75-1.29) | 0.906 | 45/165 | 33.5 | 0.80(0.60-1.08) | 0.141 | ||
| rs373759 | ||||||||||
| TT | 122/227 | 25.2 | 0.508 | 1.00 | 103/227 | 35.6 | 0.103 | 1.00 | ||
| TC | 157/294 | 23.1 | 1.14(0.90-1.45) | 0.286 | 117/294 | 34.9 | 1.08(0.82-1.41) | 0.590 | ||
| CC | 104/199 | 29.0 | 0.99(0.76-1.30) | 0.968 | 73/199 | 44.9 | 0.81(0.60-1.10) | 0.814 | ||
| Trend | ||||||||||
| TT | 122/227 | 25.2 | 0.908 | 1.00 | 103/227 | 35.6 | 0.489 | 1.00 | ||
| TC+CC | 261/493 | 24.5 | 1.07(0.87-1.34) | 0.496 | 190/493 | 41.8 | 0.96(0.75-1.22) | 0.739 | ||
| TT+TC | 279/521 | 29.0 | 0.324 | 1.00 | 220/521 | 35.4 | 0.035 | 1.00 | ||
| CC | 104/199 | 24.7 | 0.92(0.73-1.17) | 0.505 | 73/199 | 44.9 | 0.78(0.60-1.02) | 0.074 | ||
| Number of risk allele* | ||||||||||
| 0 | 14/35 | 33.6 | <0.001 | 1.00 | 7/35 | - | 0.002 | 1.00 | ||
| 1 | 85/155 | 24.5 | 1.37(0.78-2.41) | 0.279 | 58/155 | 52.9 | 1.59(0.73-3.49) | 0.244 | ||
| 2 | 164/310 | 26.7 | 1.30(0.75-2.42) | 0.138 | 137/310 | 36.9 | 1.82(0.85-3.89) | 0.122 | ||
| 3 | 106/180 | - | 1.53(1.13-2.66) | 0.004 | 81/180 | 35.5 | 2.01(1.13-4.35) | 0.017 | ||
| 4 | 14/40 | 19.7 | 2.91(1.43-3.93) | <0.001 | 10/40 | 28.6 | 1.42(1.22-2.95) | <0.001 | ||
Pa, Log-rank P; Pb, cox regression for adjusting age, gender, smoking, histology, stage, treatment, radiation technique, does; MST, median survival time.
Trend: the prognosis showed an increased or decreased changed with the number of risk allele.
*Number of risk allele: For rs664143(A) and rs189037(G): 0(GG+AA), 1(GG+AG, GA+AA), 3(AA+AG, GA+GG), 4(AA+GG).