Table 5. Subgroup multivariate analysis of clinical parameters for 189037 and survival outcomes.
| Parameters | Subgroup | Genotype | Disease-free survival | Overall survival | ||||||||
| Event/No. | MST (month) | Pa | HR*(95%CI) | Pb | Event/No. | MST (month) | Pa | HR*(95%CI) | Pb | |||
| rs189037 | ||||||||||||
| Smoking | Yes | AA | 24/71 | - | 1.00 | 24/71 | 43.5 | |||||
| AG | 121/214 | 24.5 | 0.014 | 1.61(0.97-2.66) | 0.063 | 122/214 | 34.6 | 0.055 | 1.31(0.78-2.19) | 0.309 | ||
| GG | 43/85 | 24.1 | 0.039 | 1.67(1.06-2.60) | 0.023 | 37/85 | 31.8 | 0.166 | 1.90(1.22-2.95) | 0.004 | ||
| AG+GG | 164/299 | 24.5 | 0.012 | 1.65(1.08-2.55) | 0.022 | 159/299 | 32.1 | 0.010 | 1.71(1.11-2.63) | 0.015 | ||
| No | AA | 26/94 | 59.3 | 1.00 | 21/94 | - | ||||||
| AG | 70/169 | 40.4 | 0.184 | 1.40(1.09-2.0) | 0.046 | 70/169 | 36.9 | 0.095 | 1.08(0.58-2.03) | 0.800 | ||
| GG | 25/87 | 61.4 | 0.017 | 1.05(1.01-1.83) | 0.035 | 19/87 | - | 0.027 | 1.78(1.09-2.90) | 0.021 | ||
| AG+GG | 95/256 | 44.5 | 0.015 | 1.29(1.13-2.00) | 0.025 | 89/256 | 42.9 | 0.025 | 1.57(1.09-2.53) | 0.045 | ||
| Histology | SCC | AA | 28/45 | 22.7 | 1.00 | 14/45 | 73.5 | 1.00 | ||||
| AG | 49/80 | 23.5 | 0.836 | 0.62(0.33-1.16) | 0.136 | 35/80 | 32.1 | 0.353 | 0.62(0.26-1.47) | 0.276 | ||
| GG | 15/33 | - | 0.153 | 0.95(0.60-1.51) | 0.832 | 8/33 | - | 0.383 | 1.34(0.72-2.49) | 0.354 | ||
| AG+GG | 64/113 | 22.7 | 0.110 | 1.56(0.90-2.72) | 0.115 | 43/113 | 38.1 | 0.067 | 1.98(0.64-4.190 | 0.073 | ||
| ADC | AA | 51/90 | 22.5 | 1.00 | 33/90 | 64.3 | 1.00 | |||||
| AG | 107/178 | 20.7 | 0.034 | 1.73(1.17-2.56) | 0.006 | 102/178 | 31.5 | 0.089 | 0.65(0.38-1.11) | 0.653 | ||
| GG | 33/90 | 43.1 | 0.007 | 1.80(1.16-2.78) | 0.009 | 23/90 | 58.4 | 0.000 | 1.46(0.99-2.170 | 0.057 | ||
| AG+GG | 140/268 | 21.5 | 0.003 | 1.75(1.20-2.55) | 0.003 | 125/268 | 34.6 | 0.002 | 2.01(1.29-3.13) | 0.002 | ||
| Other | AA | 15/37 | 33.3 | 1.00 | 9/37 | - | 1.00 | |||||
| AG | 65/125 | 28.9 | 0.271 | 0.92(0.55-1.51) | 0.729 | 55/125 | 36.9 | 0.318 | 1.41(0.61-3.25) | 0.426 | ||
| GG | 20/42 | 24.7 | 0.154 | 0.64(0.33-1.25) | 0.194 | 14/42 | - | 0.995 | 1.80(0.89-3.65) | 0.101 | ||
| AG+GG | 85/167 | 30.8 | 0.505 | 0.85(0.52-1.38) | 0.508 | 69/167 | 37.8 | 0.629 | 1.15(0.65-2.06) | 0.631 | ||
| Stage | IIIA | AA | 25/90 | 58.6 | 22/90 | - | ||||||
| AG | 77/162 | 60.2 | 0.051 | 1.09(0.62-1.91) | 0.760 | 77/162 | 46.0 | 0.085 | 1.07(0.58-1.97) | 0.832 | ||
| GG | 25/81 | 33.9 | 0.037 | 1.59(1.01-2.50) | 0.044 | 20/81 | - | 0.012 | 1.85(1.15-2.97) | 0.011 | ||
| AG+GG | 102/243 | 39.0 | 0.012 | 1.43(1.31-2.22) | 0.037 | 97/243 | 42.7 | 0.045 | 1.62(1.02-2.57) | 0.042 | ||
| IIIB | AA | 25/75 | 43.7 | 1.00 | 23/75 | 44.3 | 1.00 | |||||
| AG | 114/221 | 30.1 | 0.032 | 1.59(1.02-2.48) | 0.042 | 115/221 | 40.2 | 0.250 | 1.35(0.80-2.28) | 0.267 | ||
| GG | 43/91 | 27.1 | 0.037 | 1.45(1.28-2.39) | 0.031 | 36/91 | 33.2 | 0.009 | 1.86(1.18-2.94) | 0.008 | ||
| AG+GG | 157/312 | 27.1 | 0.028 | 1.55(1.05-2.38) | 0.029 | 151/312 | 33.7 | 0.019 | 1.69(1.09-2.65) | 0.020 | ||
| Treatment | RT | AA | 23/71 | - | 1.00 | 22/71 | 48.4 | 1.00 | ||||
| AG | 110/218 | 28.1 | 0.027 | 1.54(0.98-2.43) | 0.059 | 111/218 | 41.7 | 0.167 | 1.39(0.82-2.36) | 0.221 | ||
| GG | 44/91 | 30.1 | 0.019 | 1.49(1.19-2.48) | 0.021 | 38/91 | 34.9 | 0.026 | 1.78(1.12-2.82) | 0.015 | ||
| AG+GG | 154/309 | 29.0 | 0.035 | 1.53(1.08-2.38) | 0.049 | 149/309 | 34.9 | 0.036 | 1.65(1.06-2.59) | 0.028 | ||
| CRT | AA | 27/94 | 61.4 | 1.00 | 23/94 | - | 1.00 | |||||
| AG | 81/165 | 33.6 | 0.916 | 1.09(0.62-1.89) | 0.772 | 81/165 | 35.1 | 0.869 | 0.99(0.53-1.85) | 0.987 | ||
| GG | 24/81 | - | 0.029 | 1.58(1.02-2.46) | 0.040 | 18/81 | - | 0.003 | 1.87(1.17-2.97) | 0.009 | ||
| AG+GG | 105/246 | 34.5 | 0.039 | 1.43(1.02-2.20) | 0.042 | 99/246 | 36.9 | 0.029 | 1.61(1.02-2.54) | 0.041 | ||
| Does | ≥65Gy | AA | 24/85 | - | 1.00 | 23/85 | 48.4 | 1.00 | ||||
| AG | 113/232 | 29.0 | 0.069 | 1.17(0.80-1.73) | 0.420 | 114/232 | 41.7 | 0.799 | 1.23(0.82-1.86) | 0.311 | ||
| GG | 46/102 | 30.1 | 0.014 | 1.31(1.23-1.32) | 0.017 | 39/102 | 24.4 | 0.010 | 1.17(1.07-1.32) | 0.020 | ||
| AG+GG | 159/334 | 29.2 | 0.013 | 1.25(1.18-1.93) | 0.021 | 153/334 | 34.9 | 0.006 | 1.47(1.29-2.36) | 0.013 | ||
| <65Gy | AA | 26/80 | 59.3 | 1.00 | 22/80 | - | 1.00 | |||||
| AG | 78/151 | 61.4 | 0.016 | 1.68(1.02-2.76) | 0.041 | 78/151 | 35.5 | 0.133 | 1.54(0.91-2.58) | 0.104 | ||
| GG | 22/70 | 33.6 | 0.039 | 1.70(1.09-2.66) | 0..019 | 17/70 | - | 0.007 | 1.98(1.26-3.11) | 0.003 | ||
| AG+GG | 100/221 | 38.7 | 0.014 | 1.70(1.10-2.61) | 0.017 | 95/221 | 36.9 | 0.013 | 1.84(1.18-2.86) | 0.007 | ||
Pa, Log-rank P; Pb, multivariate cox regression; MST, median survival time; RT, radiation therapy; CRT, chemoradiation therapy.