Figure 1.

Colocalization of the ZNF664 eQTL with the 2nd signal (rs863750) of the two independent GWAS signals at CCDC92–ZNF664. (A) Initial variant association with WHRadjBMI in GIANT. Color indicates LD (r²) with GWAS variant of 1st signal (rs4765219). (B) Residual association with WHRadjBMI after accounting for the effect of the 1st GWAS signal in GIANT; the GWAS variant rs863750 (representing the 2nd signal) was plotted as the lead variant. (C) Variant association with ZNF664 expression levels in METSIM. The GWAS variant rs863750 representing the secondary signal was plotted as the lead variant.