Table 2. Pooled data categorized per BTTS method, including heterogeneity analysis.
| BTTS method | Number of study subsets | Pooled sensitivity (95% CI) | Pooled specificity (95% CI) | AUC (95% CI) | Inconsistency index (I2) | Number of lesions | Number of malignant lesions | Number of benign lesions | ADC threshold (10−3 mm2/s) Min-Max (Range) | ADC threshold (10−3 mm2/s) Mean (sd) |
|---|---|---|---|---|---|---|---|---|---|---|
| BTTS 1: | 7 | 0.82 [0.72–0.89] | 0.79 [0.65–0.89] | 0.88 [0.85–0.90] | 93 | 745 | 545 | 200 | 0.910–1.600 (0.690) | 1.155 (0.22) |
| BTTS 2: | 22 | 0.91 [0.89–0.93] | 0.84 [0.80–0.87] | 0.94 [0.91–0.96] | 0 | 2139 | 1381 | 758 | 0.870–1.450 (0.580) | 1.179 (0.17) |
| BTTS 3: | 19 | 0.89 [0.86–0.92] | 0.90 [0.85–0.93] | 0.95 [0.93–0.96] | 77 | 1579 | 1026 | 553 | 0.980–1.480 (0.500) | 1.191 (0.14) |
| BTTS 4: | 17 | 0.90 [0.86–0.93] | 0.84 [0.81–0.87] | 0.86 [0.82–0.88] | 86 | 1828 | 1030 | 798 | 0.690–1.580 (0.890) | 1.122 (0.22) |
| Total: | 65 | 95 | 6291 | 3982 | 2309 | 0.690–1.600 (0.910) | 1.164 (0.18) |
CI = confidence interval, ADC = apparent diffusion coefficient, BTTS = breast tumor tissue selection. BTTS1: whole breast tumor tissue selection, BTTS2: subtracted whole breast tumor tissue selection, BTTS3: circular breast tumor tissue selection and BTTS4: lowest diffusion breast tumor tissue selection.