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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Exp Neurol. 2020 Mar 9;328:113282. doi: 10.1016/j.expneurol.2020.113282

Fig. 2. Identification of drugs that alter neuronal bioenergetics by the Mito Stress Test.

Fig. 2

A & B) OCR of primary cortical neurons following the injection of 10 μM drug or vehicle control (CON), with ABT-737 added in A and UK5099 in B. The Mito Stress Test was conducted subsequent to the injection of the test drug, which consisted of the sequential addition of oligomycin (Oligo, 0.3 μg/ml), followed by FCCP (3 μM) or 2,4-dinitrophenol (DNP, 200 μM), and then antimycin A (Anti A, 1 μM). OCR values are means ± SD from three wells (with the exception of CON in B, which is the mean of two wells). OCR are baseline-normalized as in Fig. 1.