Table 2.
CML gene expression profiling.
| GENE ID | function | output on | ref |
|---|---|---|---|
| inflammation/ | |||
| immune resp | |||
| ANXA4 | high in Sjogren | anti infl | [87] |
| ARG1 | immunosuppressive | pro immun | [97] |
| BTK | sustains GVHD | anti infl | [38] |
| C3AR1 | neutrophils chemotaxis antagonist | pro immun | [98] |
| CAMP | increased in inflammation | anti infl | [126] |
| CASP10 | increased in Chron | anti infl | [88] |
| CDC20 | increased in the adiposity inflamm model | anti infl | [127] |
| CEACAM1 | inhibits T lynf | pro immun | [99] |
| CEACAM8 | high in arthritis | anti infl | [89] |
| CLEC5A | high in neurogen shock | anti infl | [92] |
| COL17A1 | induce IL7 that sustains T & B lynf | anti immun | [128] |
| CTSG | high in rheumatic arthritis | anti infl | [90] |
| CXCL2 | high in Alzheimer | anti infl | [70] |
| CXCL3 | sustain adipogenesis | anti infl | [129] |
| CYBB | increased in inflammation | anti infl | [130] |
| DAGLB | sustains production of arachidonic acid | anti infl | [131] |
| ELANE | high in LPS inflammation | anti infl | [132] |
| EPX | high in asthma | anti infl | [133] |
| FGFR1 | high in prostatic inflammation | anti infl | [134] |
| FUT4 | increased in bacterial infections | anti infl | [135] |
| GENE ID | function | output on | ref | |
|---|---|---|---|---|
| inflammation | ||||
| GRN | high in dementhia | anti | [94] | |
| GSN | increases NK apoptosis | pro immun | [100] | |
| IL18 | high in arthritis | anti | [91] | |
| ITGAM | high in psoriasis | anti | [95] | |
| LTA4H | high after trauma | anti | [113] | |
| MAP2K1 | high in sinusitis | anti | [114] | |
| MMP8 | high in intra-amniotic infections | anti | [115] | |
| MMP9 | high in skin healing | anti | [116] | |
| MPO | high in neutrophils | anti | [117] | |
| NECTIN1 | high in Chlamidial infection | pro imm | [101] | |
| OLR1 | NFkB activator | anti | [118] | |
| PGLYRP1 | high in gengivitis | anti | [96] | |
| PLAU | high after thrombosis | anti | [119] | |
| PRG2 | eosinophils basic protein | anti | [120] | |
| PTX3 | increased by IL6 | anti | [121] | |
| RNASE2 | high in inflamm, anti-viral | anti | anti-imm | [125] |
| RNASE3 | anti viral | anti imm | [125] | |
| SPTBN1 | reduces TGFb | pro | [122] | |
| TM7SF3 | reduces nitric oxid | pro | [123] | |
| TNFAIP8 | high in inflamm | anti | [124] | |
| GENE ID | function | output on |
ref | |
|---|---|---|---|---|
| inflammation | ||||
| CCL5 | activates NK | pro immun | [138] | |
| CCR4 | high in asthma | pro | [137] | |
| CCR5 | activates NK | pro immun | [136] | |
| CD28 | inactivated by PD1 | pro immun | [139] | |
| CD74 | increases MCHII expression | pro immun | [140] | |
| CX3CR1 | high in antifungal resp | pro immun | [141] | |
| CXCL16 | high in anti-viral resp | pro-immun | [105] | |
| CXCR3 | high in T effector | pro immun | [142] | |
| FYN | high in inflamm/sustains NK | pro | pro imm | [143] |
| HAVCR2 | high in anti-viral resp | pro-immun | [106] | |
| IFNG | antiviral | pro immun | [107] | |
| JAK3 | shift from M1 to M2 resp | anti | [102] | |
| NFATC2 | increases T memory | pro immun | [144] | |
| PDE4A | low in sepsis | anti | [145] | |
| SERPINB9 | activates CD8 | pro immun | [146] | |
| SOCS3 | low in arthritis | anti | [103] | |
| STAT5A | high in colon inflamm | pro | [147] | |
| TLR3 | anti-viral/anti-inflamm | anti | pro imm | [104] |
Table represents all genes that resulted Up- (in red) and down- (in green) regulated after 6 months of treatment with Imatinib, as listed in Table 1. Table 2 in addition for each gene reports the respective physiological function (with correspondent literature references) and the final effect resulting from mRNA de-regulation made by 6 months of Imatinib, with focus on the inflammation and on the immunological infection control.