Table 3.
Table reports the comparison of several features (hematological indication, safety, cost) in different hematological drugs that might have a role in the COVID-19. Abbreviations: MPN = chronic myeloproliferative neoplasms; MAS = macrophage activation syndrome; CML = chronic myeloid leukemia; ALL = acute lymphoblastic leukemia; GIST = stromal gastro-intestinal tumor; GVHD = graft-versus-host disease; LNH = non Hodgkin’s lymphoma; MM = multiple myeloma.
| Ruxolitinib | Imatinib | Dasatinib | Nilotinib | Bosutinib | Ibrutinib | Begelomab | IFN | ||
|---|---|---|---|---|---|---|---|---|---|
| Drug | os | os | os | os | os | os | IV | os | |
| formulation | |||||||||
| Clinical use in | |||||||||
| GVHD | XX | X | X | X | – | XX | XX | – | |
| Use in | MPNs | CML | CML | CML | CML | CLL | GVHD | CML | |
| hematological | MAS | ALL | ALL | ALL | MCL | MPN | |||
| diseases | GIST | LNH | |||||||
| MM | |||||||||
| Infection rate | 20 % | 5% | 11 % | 17 % | 4% | 71 % | 10 % | na | |
| Estimated | ++ | + | + | + | + | +++ | +++ | + | |
| costs |