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. 2020 May 6;6(19):eaaz0295. doi: 10.1126/sciadv.aaz0295

Fig. 5. Effect of TBSV-derived particles on the severity of CIA.

Fig. 5

Arthritic scores in each group were assessed every 2 to 3 days starting from days 24 to 59 after immunization. (A) Comparison of saline-treated CIA mice (control) to CIA mice treated with dexamethasone, TBSV.pFADK2, or pFADK2 + IFA. (B) Comparison of saline-treated CIA mice (control) to CIA mice treated with dexamethasone, TBSV.pLIP1, or pLIP1 + IFA. (C) Comparison of saline-treated CIA mice (control) to CIA mice treated with wt TBSV, TBSV.pLIP1, or TBSV.pFADK2. Each time point represents the mean arthritic score ± SEM (n = 5). Statistical significance was determined by applying the Kruskal-Wallis test followed by Dunn’s multiple comparison test. Values of P < 0.05 were considered significant. Significance was established for CIA mice treated with dexamethasone versus saline-treated CIA mice and for CIA mice treated with TBSV.pLIP1 versus saline-treated CIA mice.