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. 2020 May 6;6(19):eaay4313. doi: 10.1126/sciadv.aay4313

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4 — (A) ISF is associated with a modulation of axonal spike amplitude. Left: Recording configuration. Simultaneous whole-cell recordings from the soma and cut end axon in L5 pyramidal cells were obtained. Middle: Comparison of somatic and axonal AP amplitudes evoked by asynchronous-like (black traces) and synchronous-like (red traces) inputs. Note the increased amplitude in the axon but not in the soma. Resting membrane potential: −78 mV. Right: Quantitative data (Wilcoxon test, *P < 0.05). (B) Hyperpolarization of spike threshold and increase in the slope of the spike rising-phase during ISF (Wilcoxon test, **P < 0.01). Left: Comparison of axonal spikes induced by asynchronous and synchronous inputs. Resting membrane potential: −80 mV. Middle: Phase-plot of the APs. Note the hyperpolarization of the threshold during and the increase of maximal slope during ISF. Right: Quantitative data.