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. 2020 May 6;6(19):eaav9778. doi: 10.1126/sciadv.aav9778

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Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 4 — (A) Distributions of germline variations of BRCA pathway genes found in combined datasets [Japanese GCs, TCGA GCs (9), and Korean DGCs (6)]. Only variants found in cases linked to the BRCA signature are shown. Red, Japanese; green, TCGA non-Asian. None of the patients were TCGA East Asians/Koreans (orange) who met this criterion. #, predicted to be damaging in silico; NLS, nuclear localization signal; SCD, serine cluster domain; HD, helical domain; OB, oligonucleotide binding; TR2, second RAD51-binding domain; aa, amino acid; ATP, adenosine triphosphate. (B) Distributions of germline variations of CDH1 in the same datasets as in (A). *, reported in clinically defined HDGC (strong familial aggregation or extremely early-onset case). Bold circle, diffuse-type histology. SIG, signal; TM, transmembrane domain.