Figure 2.

We approximate homeostasis by nonequilibrium, oscillatory dynamic crowding (A). After a transition state, oscillatory dynamic crowding causes suppression of genes that have a high expression at steady state, amplification of genes that have a low expression at steady state, and relatively unchanged expression of genes with midrange expression (here, [C] = 1 nM) (B). Both the steady-state and dynamic expression of each of these genes depends on the initial condition of the dynamic crowding profile. When normalized by expression at this initial condition, these genes display different sensitivities to dynamic crowding at oscillating stability (C). To see this figure in color, go online.