Figure 1.

(A) Schematic representation of commonly observed nuclear architectures for Drosophila nucleus including conventional, senescent, and inverted states observed upon loss of lamina-heterochromatin tethering (48, 49). (B) An illustration of the MELON framework is given. The nucleus is resolved by several marginally overlapping liquid-like chromosomal territories, each of which is described by an individual field variable. Within each chromosomal territory, we introduce an additional variable describing (possible) chromatin phase separation into A or B types that form hetero- or euchromatin droplets. A separate field variable is introduced for describing the elastic membrane and its relaxation dynamics during the events of nuclear growth or inversion. To see this figure in color, go online.