Figure 4.
Impact of heterochromatin volume fraction on the nuclear compartment reorganization with fixed nuclear size. Shown are nuclear morphologies generated with different heterochromatin contents: (A) ρ = 25%, (B) ρ = 30%, and (C) ρ = 45%. Simulations are initiated by terminating lamina-heterochromatin interaction, and the timescale of chromatin relaxation is set for modeling nuclear senescence and inversion τ = L−1 = 5 h. Ap = 5 for mammalian nuclei (65). To see this figure in color, go online.