Figure 6.

(A) Volume relaxation profiles of chromosomes (solid lines) and nucleus as a whole (dashed lines) as a function of remodeling time. The color code shows the different target of steady-state nuclear volumes corresponding to 10% volume expansion (black lines), volume compression by 50% (red lines), and volume compression by 60% (blue lines). (B) Temporal evolution of the number of heterochromatin cluster in the cell’s nucleus during the reorganization process with different target steady-state nuclear volumes ${\overline{V}}_N$ is shown. All simulations of the nuclear volume remodeling were initiated by terminating heterochromatin-lamina interaction term to mimic processes of senescence and nuclear inversion. The heterochromatin fraction content in the nucleus is fixed to 30%. To see this figure in color, go online.