Table 4.
Incremental value of CT based assessment of CAD using CAD-RADS categories beyond risk factors and CACS (a) in the overall population and (b) across CAC strata
| (a) | ||||
|---|---|---|---|---|
| Univariable Model |
C statistic | Multivariable models | C statistic | p-value (Diff betw. Models)* |
| ASCVD | 0.629 (0.572-0.687) | |||
| CACS | 0.657 (0.606-0.708) | ASCVD+CACS | 0.682 (0.629-0.735) | 0.008 |
| CAD-RADS(+HRP) | 0.747 (0.703-0.792) | ASCVD+CACS+CAD-RADS(+HRP) | 0.776 (0.734-0.818) | <0.001 |
| (b) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Model | CACS strata | ||||||||
| CACS 0 | CACS 1-100 | CACS >100-400 | CACS >400 | ||||||
| Description | c stat | p-value | c stat | p-value | c stat | p- value |
c stat | p-value | |
| 1 | ASCVD | 0.539 | 0.607 | 0.551 | 0.572 | ||||
| 2 | ASCVD+CAD-RADS(+HRP) | 0.751 | 0.005 | 0.775 | 0.023 | 0.673 | 0.031 | 0.697 | 0.041 |
Description: ASCVD as continuous variable; CAC as categorical variable (0, 1-100, 101-400, >400 CACS), CTA per CAD-RADS definition including HRP (Vulnerable Plaque)
*
p-value shows difference of the stepwise c-statistic comparison between the specific model and the consecutive model
p-value calculations: Modell 2 vs 1