Table 2.

Association between ER/PR/HER2 defined groups and Indigenous American genetic ancestry (for every 10% increase)

Covariates	Subtype	N	OR	95% CI	P-value
By HER2 status
Univariate	HER2−	837	Ref.
	HER2+	392	1.10	1.02–1.19	0.012
Age dx + Afr + Height	HER2−	688	Ref.
	HER2+	335	1.19	1.06–1.33	0.002
Age dx + Afr + Height + rs140068132	HER2−	688	Ref.
	HER2+	335	1.20	1.07–1.35	0.001
By ER/PR/HER2 status
Univariate	ER/PR+ HER2−	638	Ref.
	ER/PR- HER2+	156	1.22	1.08–1.37	0.001
	ER/PR+ HER2+	239	1.06	0.97–1.16	0.175
	ER/PR/HER2−	200	1.07	0.97–1.18	0.165
Age dx + Afr + Height	ER/PR+ HER2−	531	Ref.
	ER/PR- HER2+	129	1.30	1.08–1.55	0.004
	ER/PR+ HER2+	209	1.17	1.02–1.33	0.024
	ER/PR/HER2−	158	1.10	0.95–1.27	0.196
Age dx + Afr + Height + rs140068132	ER/PR+ HER2−	531	Ref.
	ER/PR- HER2+	129	1.32	1.10–1.57	0.002
	ER/PR+ HER2+	209	1.18	1.03–1.35	0.014
	ER/PR/HER2−	158	1.11	0.96–1.29	0.141

Age dx: age at diagnosis; Afr: African genetic ancestry proportion