Table 1. Serum estradiol and progesterone levels in wild-type and hCYP2D6 mice.

Assessment of ovariectomy and hormonal replacement effect on serum sex steroid hormone concentrations in wild-type C57BL/6J female mice at estrus or submitted to ovariectomy and hormonal supplementation with 17β-estradiol and/or progestrone. Estradiol and progesterone values are expressed as mean ± SE in pg/ml serum (n=10). All comparisons were made with OV Placebo. The differences between two groups were analyzed using the Student’s t-test,

WT	Estradiol (pg/ml)	Progesterone (pg/ml)
Sham at Estrous	7.2±0.7*	5154.5±889.0**
OV Placebo	4.1±0.3	554.4±79.5
OV Estradiol	89.5±12.8***	3029.4±868.4**
OV Progesterone	7.2±2.8	3525.9±362.7***
OV Estradiol plus Progesterone	56.8±8.9***	5618.4±380.9***
hCYP2D6
Sham at Estrous	5.1±0.9**	569.4±94.9**
OV Placebo	2.6±0.5	185.8±32.9
OV Estradiol	54.1±9.0***	603.6±147.0*
OV Progesterone	4.5±0.9	1055.7±103.7***
OV Estradiol plus Progesterone	32.0±4.9***	4382.5±900.1***

^*P<0.05,

^**P<0.01,

^***P< 0.001.