Table 2:

Clinical Outcomes

	Standard							Refractory
	CD45-depleted haploHCT	Initial haploHCT	P value	Recent haploHCT	P value	Contemporary HLA-matched	P value	CD45-depleted haploHCT	Recent haploHCT	P value
Number	36	24		51		40		14	15
1 year OS	88.1% (±6.1%)	45.8% (±9.7%)		68.6% (±6.4%)		84.2% (±6.2%)		53.9% (±14.9%)	33.3% (±11.1%)
3 year OS	78.9% (±13.7%)	33.3% (±9.6%)	0.0005	52.9% (±7.0%)	0.03	66.0% (±10.3%)	0.4	32.3% (±18.8%)	20.0% (±10.3%)	0.4
1 year EFS	82.9% (±7.2%)	37.5% (±9.4%)		58.8% (±6.8%)		65.2% (±8.0%)		41.7% (±15.9%)	26.7% (±10.2%)
3 year EFS	77.7% (±13.9%)	25.0% (±8.8%)	0.0001	51.0% (±7.0%)	0.02	62.0% (±10.6%)	0.2	27.8% (±16.7%)	20.0% (±10.3%)	0.64
100 day TRM	2.8% (±2.8%)	12.5% (±9.6%)		11.8% (±4.6%)		2.5% (±2.5%)		21.4% (±11.4%)	6.7% (±6.7%)
1 year TRM	5.6% (±3.9%)	41.7% (±10.4%)	0.001	21.6% (±5.8%)	0.05	7.9% (±4.4%)	0.7	21.4% (±11.4%)	33.3% (±13.0%)	0.67
1yr relapse rate	11.5% (±5.5%)	25.0% (±9.1%)		19.6% (±5.6%)		27.0% (±7.5%)		36.9% (±14.1%)	53.3% (±13.6%)
3yr relapse rate	11.5% (±5.5%)	33.3% (±10.1%)	0.02	23.5% (±6.0%)	0.2	30.3% (±7.9%)	0.1	36.9% (±14.1%)	53.3% (±13.6%)	0.3

	All Patients
	CD45-depleted haploHCT	Initial haploHCT	P value	Recent haploHCT	P value	Contemporary HLA-matched
Number	50	27		66		43
II-IV acute GVHD	32.1% (±6.7%)	22.2% (±8.2%)	0.3	36.4% (±6.0%)	0.8	32.9 (±7.3%)	0.9
III-IV acute GVHD	28.1% (±6.4%)	7.4% (±5.1%)	0.04	24.2% (±5.3%)	0.5	18.75 (±6.1%)	0.2
chronic GVHD	25.9% (±6.6%)	25.9% (±8.7%)	1.00	27.3% (±5.5%)	0.7	10.3 (±5.0%)	0.05