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. Author manuscript; available in PMC: 2020 Aug 10.

Published in final edited form as: Adv Healthc Mater. 2019 Nov 7;9(15):e1900977. doi: 10.1002/adhm.201900977

Figure 5. — Release kinetics of various structures with different compositions and shell thicknesses. A) Release profile of HA-GM-only versus HA-GM with Hep-SH core-only versus core–shell structure. Two-way repeated measures ANOVA with Sidak post hoc tests revealed that incorporating Hep-SH () into the HA-GM-only () hydrogel significantly decreased the amount of GF released retained the GF for all time points (p < 0.0001). Furthermore, an additional layer of Hep-SH not containing any GF () was found to further decrease total GF releases after day 8 (p = 0.036 to p < 0.0001). B) Release profile of core–shell structures with different shell thicknesses. Doubling the layer thickness reduced the release rates after day 3 (p = 0.0137 to p < 0.0001) whereas halving the layer increased the release after day 14 (p = 0.0009 to p < 0.0001). Data presented as mean ± SD, n = 4 for all data points

Inline graphic — Release kinetics of various structures with different compositions and shell thicknesses. A) Release profile of HA-GM-only versus HA-GM with Hep-SH core-only versus core–shell structure. Two-way repeated measures ANOVA with Sidak post hoc tests revealed that incorporating Hep-SH () into the HA-GM-only () hydrogel significantly decreased the amount of GF released retained the GF for all time points (p < 0.0001). Furthermore, an additional layer of Hep-SH not containing any GF () was found to further decrease total GF releases after day 8 (p = 0.036 to p < 0.0001). B) Release profile of core–shell structures with different shell thicknesses. Doubling the layer thickness reduced the release rates after day 3 (p = 0.0137 to p < 0.0001) whereas halving the layer increased the release after day 14 (p = 0.0009 to p < 0.0001). Data presented as mean ± SD, n = 4 for all data points