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. Author manuscript; available in PMC: 2020 Aug 10.

Published in final edited form as: Adv Healthc Mater. 2019 Nov 7;9(15):e1900977. doi: 10.1002/adhm.201900977

Figure 7. — Sequential release of VEGF and PDGF. A) Schematics of structural designs. B) Release profile of nonhierarchical structure. PDGF () was found to have a higher diffusion rate than VEGF () with p = 0.0115. C) Release profile of structure with shell containing VEGF () and core containing PDGF (). The geometrical design reduced the diffusion of VEGF as compared to PDGF (p < 0.0001). D) Release profile of structure with reversed spatial order with PDGF in the shell () and VEGF in the core (). The PDGF was found to diffuse faster than VEGF in this design (p < 0.0001). Data presented as mean ± SD, n = 4.

Inline graphic — Sequential release of VEGF and PDGF. A) Schematics of structural designs. B) Release profile of nonhierarchical structure. PDGF () was found to have a higher diffusion rate than VEGF () with p = 0.0115. C) Release profile of structure with shell containing VEGF () and core containing PDGF (). The geometrical design reduced the diffusion of VEGF as compared to PDGF (p < 0.0001). D) Release profile of structure with reversed spatial order with PDGF in the shell () and VEGF in the core (). The PDGF was found to diffuse faster than VEGF in this design (p < 0.0001). Data presented as mean ± SD, n = 4.