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. Author manuscript; available in PMC: 2021 May 5.
Published in final edited form as: Anal Chem. 2020 Apr 16;92(9):6341–6348. doi: 10.1021/acs.analchem.9b05274

Figure 6.

Figure 6.

(a) ARSA activity after size-exclusion chromatography purification in DBS from 34 MLD patients (median: 0.0015 μM/h, range: 0–0.18 μM/h), 3 MSD patients (median: 0.032 μM/h, range: 0.028–0.076 μM/h), 10 healthy adults (median: 0.80 μM/h, range: 0.45–1.3 μM/h) and 294 random newborns (median: 0.27 μM/h, range: 0.082–0.65 μM/h). Fresh DBS from patients and healthy adults were used. (b)ARSA activity in aged DBS (stored at room temperature for 1 month before processing) from 18 MLD patients (median: 0.003 μM/h, 0–0.043 μM/h), 2 MSD patients (0.021 and 0.035 μM/h), and 205 random newborns (median: 0.21 μM/h, 0.073–0.56 μM/h. The horizontal bar indicates the median of each group.