Table 2.

Brain regions with decreased functional connectivity (FC) in migraine without aura (MWoA) compared to healthy controls (HC)

Predominant regions in the cluster	Cluster size	Peak T	MNI coordinates			pFWE − corr
	(number of voxels)		x	y	z
Seed in L M1
Right middle occipital gyrus	199	−5.28	36	−69	3	0.000
Right middle temporal gyrus	151	−5.19	57	−57	0	0.000
Right superior temporal gyrus	177	−4.85	63	−27	15	0.000
Parietal_Sup_L (aal)	303	−4.73	−30	− 48	57	0.000
Right postcentral gyrus	342	−4.51	30	−45	66	0.000
Right middle frontal gyrus	135	−4.44	36	−3	48	0.001
Seed in R M1
Right middle occipital gyrus	122	−5.00	36	−69	6	0.002
Right superior temporal gyrus	60	−4.59	63	−27	15	0.046
Parietal_Sup_L (aal)	307	−4.57	− 30	− 45	57	0.000
Postcentral_R (aal)	164	−4.24	33	−42	57	0.000
Right cuneus	64	−3.97	21	−93	18	0.036
Seed in L S1
Precuneus_L (aal) extending to	176 (971)	−5.73	−9	−48	69	0.000
Bilateral postcentral gyrus	229 (971)
Bilateral Paracentral lobule	210 (971)
Precuneus_R (aal)	112 (971)
Right middle temporal gyrus	144	−5.25	57	−54	0	0.001
Right superior temporal gyrus	195	−4.96	63	−30	15	0.000
Left inferior parietal lobule	157	−4.84	−57	−39	21	0.000
Left middle temporal gyrus	108	−4.58	−45	−66	12	0.004
Right inferior frontal gyrus	61	−4.54	48	33	9	0.047
Postcentral_L (aal)	76	−4.22	−21	−30	66	0.020
Right middle frontal gyrus	112	−4.22	45	0	45	0.003
Seed in R S1
Precuneus_R (aal) extending to	166 (1219)	−5.13	12	−42	63	0.000
Precuneus_L (aal)	98 (1219)
Right cingulate gyrus	67 (1219)
Bilateral postcentral gyrus	320 (1219)
Bilateral paracentral lobule	252(1219)
Bilateral precentral gyrus	246(1219)
Right superior temporal gyrus	86	−4.78	63	−30	15	0.011
Left inferior parietal lobe	61	−4.59	− 60	− 42	21	0.046
Occipital_Sup_L (aal)	87	−4.13	−21	−60	18	0.010
Seed in L SMA
Precentral_L (aal) extending to	95 (665)	−5.62	−51	0	42	0.000
Left precuneus	112 (665)
Parietal_Inf_L (aal)	210 (665)
Postcentral_L (aal)	198 (665)
Right middle frontal gyrus extending to	131 (852)	−5.55	36	−6	51	0.000
Right inferior parietal lobule	145 (852)
Postcentral_R (aal)	274 (852)
Precentral_R (aal)	177 (852)
Right cuneus	217 (605)	−5.22	15	−78	30	0.000
Left middle temporal gyrus	77 (605)
Right superior temporal gyrus	76	−4.95	63	−27	15	0.020
Right middle temporal gyrus	267	−4.72	60	−54	6	0.000
Seed in R SMA
Right middle frontal gyrus extending to	104 (1942)	−5.57	39	−6	51	0.000
Bilateral postcentral gyrus	373 (1942)
Bilateral precentral Gyrus	330 (1942)
Bilateral inferior parietal lobule	243 (1942)
Bilateral cuneus	232 (1942)
Bilateral precuneus	221 (1942)
Right middle temporal gyrus	91	−4.28	57	−54	−6	0.009
Seed in R preSMA
Left precuneus	110	4.05	−18	−72	39	0.004
Seed in R PMd
Left precuneus	306	−4.88	−18	−57	54	0.000
Left middle occipital gyrus	200	−4.75	−36	−78	9	0.000
Cerebellum_8_R	83	−4.49	18	−60	−57	0.013
Right cuneus	144	−4.47	21	−93	18	0.001
Right middle occipital gyrus	103	−4.11	36	−81	0	0.005
Right postcentral gyrus	101	−4.11	9	−45	66	0.005
Left cuneus	68	−3.84	− 18	− 87	18	0.031
Seed in L PMv
Left precentral gyrus	107	−4.50	−27	−30	57	0.004
Right cingulate gyrus	111	−3.92	−9	−9	39	0.003
Right postcentral gyrus	75	−3.77	12	−45	69	0.022
Seed in R PMv
Bilateral precuneus extending to	139 (469)	−4.75	12	−45	63	0.000
Bilateral postcentral gyrus	173 (469)
Supp_Motor_Area_L (aal)	109	−4.32	0	−18	51	0.004

The results were assigned thresholds at p < 0.001 (voxel level) and FWE corrected to p < 0.05 at the cluster level