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. 2020 May 6;10:7656. doi: 10.1038/s41598-020-64601-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ophthalmologic and PS-OCT images of the left eye of a patient with AMD. Colour fundus photograph (a), fundus autofluorescence (AF) images (b,c), and fluorescein angiography image (d) of the left eye of a patient with dry age-related macular degeneration. AF images were taken at 532 (b) and 787 (c) nm. Polarization-sensitive optical coherence tomography intensity (left) and en face entropy (right) map excluding the effect of choroidal melanin (e), as described in Methods, and cross-sectional B-scan images (f) of the left eye of the patient. In (e,f), asterisk indicates a signal artefact; arrowheads indicate the possible presence of melanin-containing retinal pigment epithelial cells, showing high entropy on the surface of sub-retinal hyper-reflective mass; double arrows indicate the atrophy area.