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. 2020 May 6;10:7656. doi: 10.1038/s41598-020-64601-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantitative evaluation of entropy of RPEs of diseased, healthy, and hiPSC-RPE sheet in-vivo. Quantitative evaluation of entropy-related cross-sectional B-scan images from the patient retinas presented in Figs. 3–5. Entropy B-scan images and entropy plot for the left (a) and right (b) eyes of a patient with dry age-related macular degeneration and for the eye with transplanted autologous human induced pluripotent stem cell-derived retinal pigment epithelial (hiPSC-PRE) cell sheet (c). Orange, yellow, and purple ranges in the graph mean the intact RPE, atrophic or defective RPE, and hiPSC-RPE areas, respectively. Mean entropy values are shown as triangles. Measurement area of 100 (width) × 3 (depth) pixels is shown by white lines in B-scan entropy images.