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. 2020 May 6;10:7616. doi: 10.1038/s41598-020-64400-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functionality of MRP1, MRP2 and the different chimera expressed in FlpIn 293 cell line. (a) Basal GSH efflux: total intracellular GSH contents were quantified in respect of the same cells transfected with the empty vector (Control, 100%). (b-e) MDR phenotype: doxorubicin (b,c) and vincristine cytotoxicity (d,e) in cells expressing, or not, the different proteins. EC₅₀ values are concentrations at which doxorubicin (c) and vincristine (e) kill 50% of the cell population. Data are the means ± SD of triplicate determinations of N ≥ 3 biologically independent assays. **p ≤ 0.01 and ***p ≤ 0.001 based on a two-tailed paired t test.