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. 2020 May 6;10:7616. doi: 10.1038/s41598-020-64400-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Characterization of collateral sensitivity dependent on MRP1, MRP2, M2, M5, M6 and M8 chimeras. (a) Quantification of total intracellular GSH contents in cells in the presence of DMSO (black bars) or verapamil (white bars), in respect of the same cells treated with DMSO as a control (DMSO 100%). (b,c) CS evaluation after a 72-h incubation with verapamil, in the presence of 5 µM of L-BSO. EC₅₀ values are concentrations at which verapamil in presence of L-BSO at 5 µM kill 50% of the cell population. Data are the means ± SD of triplicate determinations of three independent assays. *p ≤ 0,05, **p ≤ 0.01 and ***p ≤ 0.001 (two-tailed paired t test).