Table 2.
Univariable and multivariable analyses of Ki-67 and grade on RFS in breast cancer patients among IHC-based subtypes.
| All subtypes | Luminal-like | HER2-positive | TNBC | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% Cl | P | HR | 95% Cl | P | HR | 95% Cl | P | HR | 95% Cl | P | |
| Univariable | ||||||||||||
| Ki-67 (categorical)* | ||||||||||||
| Low (reference) | ||||||||||||
| High | 1.86 | 1.43–2.42 | <0.001 | 1.97 | 1.39–2.80 | <0.001 | 1.26 | 0.76–2.10 | 0.373 | 1.38 | 0.64–3.00 | 0.413 |
| Grade | ||||||||||||
| 1, 2 (reference) | ||||||||||||
| 3 | 1.77 | 1.38–2.28 | <0.001 | 2.15 | 1.50–3.06 | <0.001 | 0.99 | 0.63–1.54 | 0.951 | 1.51 | 0.74–3.09 | 0.255 |
| Multivariable** | ||||||||||||
| Ki-67 (categorical)* | ||||||||||||
| Low (reference) | ||||||||||||
| High | 1.6 | 1.21–2.12 | 0.001 | 1.88 | 1.31–2.69 | 0.001 | 1.12 | 0.67–1.87 | 0.667 | 1.62 | 0.73–3.58 | 0.234 |
| Grade | ||||||||||||
| 1, 2 (reference) | ||||||||||||
| 3 | 1.38 | 1.05–1.80 | 0.021 | 1.97 | 1.36–2.85 | <0.001 | 0.8 | 0.51–1.27 | 0.35 | 1.31 | 0.63–2.71 | 0.466 |
Abbreviations: RFS, recurrence-free survival; IHC-based, immunohistochemical-based; HER2, human epidermal growth factor receptor 2; TNBC, triple-negative breast cancer; HR, hazard ratio; CI, confidence interval.
* Ki-67 median = 15%, Ki-67 Low <15%, Ki-67 High ≥ 15%.
** Cox proportional hazard models adjusting for tumour stage, lymph stage, lymphatic vessel invasion (LVI) and IHC-based subtype as covariates.