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. 2020 May 6;11(5):322. doi: 10.1038/s41419-020-2521-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a IHC showing the levels of HDAC7 and EphA2 in the NPCs and normal nasopharyngeal mucosa (NNM). Representative IHC images are shown on the top, and statistical analysis is presented on the bottom (p < 0.001, Chi-squared test). b Western blot showing the levels of HDAC7 and EphA2 in the additional four paired fresh biopsies of NPC and NNM. c Western blot showing the levels of HDAC7 in the five NPC cell lines and immortalized normal human nasopharynx epithelial cell line NP69. d Kaplan–Meier survival analysis for 107 NPC patients according to HDAC7 expression levels. NPC patients with high HDAC7 expression have a significantly worse overall survival and disease-free survival than those with low HDAC7 expression. The log-rank test was used to calculate P value.